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Pancoast Tumour (Superior Sulcus / Apical Lung Cancer)

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Pancoast Tumour (Superior Sulcus / Apical Lung Cancer) body chart
Illustrative, not diagnostic. Canva body chart for Pancoast Tumour (Superior Sulcus / Apical Lung Cancer).

The shoulder page you must know before you need it.

Illness script in one line: shoulder, scapular or medial arm pain with no mechanical cause, worse at night, unrelieved by rest or position, in a smoker or older adult, with hand weakness or numbness in a C8–T1 pattern and sometimes a drooping eyelid and small pupil on the same side.

Caseload frequency: rare. You may go a whole career without one, and you will absolutely see the presentation it hides inside — an unexplained shoulder.

The line that gets students

Classic teaching lists "normal shoulder imaging" under objective findings. Read that sentence again, because it is the trap.

A normal shoulder X-ray or ultrasound is what you'll be handed. It reassures the patient, it reassures the referrer, and it means nothing here — because the tumour is in the lung apex, not the shoulder.

"Normal shoulder imaging" doesn't mean it's clear. It means you imaged the wrong thing.

Pancoast tumour masquerading as musculoskeletal pain has been reported [1]. Read further: pulmonary pathology presenting as shoulder pain, written for physios [2], orthopaedic aspects and early diagnosis [3], shoulder pain as a diagnostic dilemma [4]. This is an old problem that keeps happening.

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Guideline anchor

No Australian guideline for the physiotherapy recognition of this presentation.

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The Australian anchor for when to investigate is Cancer Australia's Investigating symptoms of lung cancer: a guide for all health professionals (2020), which lists unexplained, persistent chest and/or shoulder pain lasting more than three weeks (earlier with risk factors) as a trigger for an urgent chest X-ray. The imaging anchor is the ACR Appropriateness Criteria for Horner syndrome (Dubey et al. 2025, PMID 41193044). The risk-profile anchor is the CHEST guideline and expert panel report on screening for lung cancer (Mazzone et al. 2021, PMID 34270968), with low-dose CT screening in a high-risk population reported in Lancet Oncology (Bhamani et al. 2025, PMID 40154514). The recognition anchor — and the most useful paper on this page for a physiotherapy student — is a report of pulmonary pathology recognised in a patient presenting with shoulder pain, published in Physiotherapy Theory and Practice (Brindisino et al. 2022, PMID 32459135), alongside a report of Pancoast tumour masquerading as musculoskeletal pain (Gadikota et al. 2025, PMID 40860246).

PubMed Source

The guidelines here govern imaging and screening decisions made by doctors. Nothing on this page is a treatment guideline, because the physiotherapy management of this condition is recognition and referral.

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Sources · 20

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Every source on this page resolves and title-verifies against PubMed. Newest first.

  1. 2025Gadikota et al. (2025). Pancoast tumor masquerading as musculoskeletal pain. Orthopedic reviews, 17, 143289. https://doi.org/10.52965/001c.143289
  2. 2022Brindisino et al. (2022). Recognition of pulmonary pathology in a patient presenting with shoulder pain. Physiotherapy theory and practice, 38(4), 597-607. https://doi.org/10.1080/09593985.2020.1768611
  3. 1973Spengler et al. (1973). Orthopaedic aspects and early diagnosis of superior sulcus tumor of lung (Pancoast). The Journal of bone and joint surgery. American volume, 55(8), 1645-50. PubMed 4804986
  4. 1984Kovach & Huslig (1984). Shoulder pain and Pancoast tumor: a diagnostic dilemma. Journal of manipulative and physiological therapeutics, 7(1), 25-31. PubMed 6716016
  5. 2021Mazzone et al. (2021). Screening for Lung Cancer: CHEST Guideline and Expert Panel Report. Chest, 160(5), e427-e494. https://doi.org/10.1016/j.chest.2021.06.063
  6. 2025Bhamani et al. (2025). Low-dose CT for lung cancer screening in a high-risk population (SUMMIT): a prospective, longitudinal cohort study. The Lancet. Oncology, 26(5), 609-619. https://doi.org/10.1016/S1470-2045(25)00082-8
  7. 2006Ichinohe et al. (2006). Delay by patients and doctors in treatment of Pancoast tumor. Wiener klinische Wochenschrift, 118(13-14), 405-10. https://doi.org/10.1007/s00508-006-0615-0
  8. 2025Laouar et al. (2025). When Patient and Clinician Miss the Signal: A Delayed Diagnosis of Pancoast Tumor. Cureus, 17(9), e91732. https://doi.org/10.7759/cureus.91732
  9. 2004Villas et al. (2004). Cervicobrachialgia and pancoast tumor: value of standard anteroposterior cervical radiographs in early diagnosis. Orthopedics, 27(10), 1092-5. https://doi.org/10.3928/0147-7447-20041001-20
  10. 2024Disse et al. (2024). Differentiation of Horner Syndrome and Physiological Anisocoria by Automated Pupillometry. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 45(3), 327-332. https://doi.org/10.1097/WNO.0000000000002262
  11. 2012Gao & Crompton (2012). Horner Syndrome: A Practical Approach to Investigation and Management. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), 1(3), 175-9. https://doi.org/10.1097/APO.0b013e318256009d
  12. 2010Almog et al. (2010). Diagnostic value of imaging in horner syndrome in adults. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 30(1), 7-11. https://doi.org/10.1097/WNO.0b013e3181ce1a12
  13. 2025Dubey et al. (2025). ACR Appropriateness Criteria® Horner Syndrome. Journal of the American College of Radiology : JACR, 22(11S), S550-S577. https://doi.org/10.1016/j.jacr.2025.08.041
  14. 1983O'Connell et al. (1983). Superior sulcus tumor: radiographic diagnosis and workup. AJR. American journal of roentgenology, 140(1), 25-30. https://doi.org/10.2214/ajr.140.1.25
  15. 2013Manenti et al. (2013). Pancoast tumor: the role of magnetic resonance imaging. Case reports in radiology, 2013, 479120. https://doi.org/10.1155/2013/479120
  16. 2025Langer et al. (2025). Therapeutic modalities for superior sulcus tumor (Pancoast) tumor - A systematic review. Lung cancer (Amsterdam, Netherlands), 206, 108640. https://doi.org/10.1016/j.lungcan.2025.108640
  17. 2026Li (2026). A minimally invasive hybrid approach to a complex challenge: VATS resection for superior sulcus tumor with literature review. Journal of cardiothoracic surgery, 21(1). https://doi.org/10.1186/s13019-026-04084-y
  18. 2026Gritsiuta et al. (2026). Superior sulcus tumor with vertebral invasion following initial diagnosis of cavitary lung disease: a case report. AME case reports, 10, 143. https://doi.org/10.21037/acr-2026-0121
  19. 2023Rao et al. (2023). Pancoast Tumor With Cardiac Metastases and Intracardiac Thrombosis. Journal of investigative medicine high impact case reports, 11, 23247096231154642. https://doi.org/10.1177/23247096231154642
  20. 2023Rahimzadeh et al. (2023). Erector Spinae Plane Block for the Treatment of Intractable Pain in a Patient with Pancoast Tumor: A Case Report. Anesthesiology and pain medicine, 13(3), e135829. https://doi.org/10.5812/aapm-135829

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